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Table 2 Carrier Rates and Incidences of Thalassemia in 17 Regions of China

From: Prevalence, mutation distribution, and economic burden of thalassemia in China: a systematic review and regional analysis

province

Cases

α- thalassemia

β- thalassemia

Carrier rate of α- and β- thalassemia

Total incidence

(‰)

Carrier rates

Adjusted carrier rate

Carrier rates

Adjusted carrier rate

Beijing [9]

11,766

0.14%

0.16%

0.10%

0.11%

N/A

 < 0.01‰

Chongqing [10]

1841

3.86%

3.86%

2.12%

2.12%

N/A

0.48‰

Fujian [11]

189,414

5.23%

5.71%

2.21%

2.39%

0.10%

1.00‰

Guangdong [7, 12, 13]

31,568

12.10%

12.10%

3.55%

3.55%

0.52%

4.39‰

Guangxi [7]

4834

19.51%

19.51%

7.05%

7.05%

N/A

10.76‰

Guizhou [7, 14, 15]

31,353

9.77%

9.77%

3.88%

3.88%

0.52%

3.13‰

Hainan [7]

2720

45.15%

45.15%

5.59%

5.59%

N/A

51.74‰

Hubei [16,17,18,19,20]

97,689

0.91%

0.99%

0.36%

0.38%

0.01%

0.07‰

Hunan [21, 22]

41,753

5.30%

5.30%

3.02%

3.02%

0.18%

1.01‰

Jiangsu [23]

4276

2.69%

2.69%

0.40%

0.40%

N/A

0.19‰

Jiangxi [24]

136,312

10.62%

10.62%

3.62%

3.62%

0.45%

3.48‰

Shandong [25]

16,098

0.32%

0.35%

0.14%

0.15%

N/A

0.04‰

Sichuan [26,27,28]

58,675

1.83%

2.00%

1.25%

1.35%

0.04%

0.15‰

Yunnan [6, 7, 29, 30]

11,133

9.59%

9.59%

4.68%

4.68%

1.00%

3.61‰

Zhejiang [31, 32]

32,581

0.68%

0.74%

1.31%

1.42%

0.03%

0.07‰

Hong Kong [33, 34]

1943

5.97%

6.52%

3.71%

4.01%

0.31%

1.63‰

Macao [35]

5741

6.20%

6.77%

3.60%

3.90%

N/A

1.53‰

  1. Both carrier rates of α-thalassemia and β-thalassemia have included the carrier rate of α- and β-thalassemia, respectively; Adjusted value for α-thalassemia carrier rate = α-thalassemia carrier rate × 1.092, Adjusted value for β-thalassemia carrier rate = β-thalassemia carrier rate × 1.082, among the 15 provinces and cities, the thalassemia carrier rate in Hainan, Guangxi, Guangdong, Guizhou, Yunnan and Hunan are all data for NGS test sampled by ethnic population proportion, and there is no need for correction